ph-reversible crosslinking (Intezyne Inc)
Structured Review

Ph Reversible Crosslinking, supplied by Intezyne Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/ph-reversible+crosslinking/pmc03306987-113-16-12?v=Intezyne+Inc
Average 90 stars, based on 1 article reviews
Images
1) Product Images from "A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs"
Article Title: A Versatile Polymer Micelle Drug Delivery System for Encapsulation and In Vivo Stabilization of Hydrophobic Anticancer Drugs
Journal: Journal of Drug Delivery
doi: 10.1155/2012/951741
Figure Legend Snippet: The IVECT polymer micelle. Drugs are loaded into the core hydrophobic block (yellow). The crosslinking block (green) provides stability to the micelle by forming pH-reversible metal-acetate bonds that allow for triggered drug release near the tumor. The PEG block (gray) gives the micelle aqueous solubility and stealth properties in vivo .
Techniques Used: Polymer, Blocking Assay, Solubility, In Vivo
Figure Legend Snippet: Metal-acetate crosslinking chemistry for stabilization of polymer micelles. While the drug is localized in the core block, the poly(aspartic acid) block of the middle block reacts with metals to form metal acetate bonds. Bonds are formed at high pH and are dissociated at low pH. M represents metal, and X represents a halogen.
Techniques Used: Polymer, Blocking Assay
Figure Legend Snippet: Drug formulation properties. The encapsulation retention percentage, crosslinking retention percentage, and particle sizes are shown for eleven compounds tested for loading within the polymer micelle.
Techniques Used: Drug Formulation, Encapsulation, Polymer